Involvement of p38 mitogen-activated protein kinase in PLL-AGE-induced cyclooxgenase-2 expression
β Scribed by Chien-Huang Lin; Chih-Hsiung Wu; Wai-Yee Thum; Yuan-Sun Ho; Horng-Mo Lee
- Book ID
- 114014574
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 445 KB
- Volume
- 438
- Category
- Article
- ISSN
- 0014-2999
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract 8βClβcAMP (8βchloroβcyclic AMP), which induces differentiation, growth inhibition and apoptosis in various cancer cells, has been investigated as a putative antiβcancer drug. Although we reported that 8βClβcAMP induces growth inhibition via p38 mitogenβactivated protein kinase (MAPK) an
## Abstract ## BACKGROUND The mitogenβactivated protein kinase (MAPK) cascade is activated in response to various extracellular stimuli. The authors investigated the involvement of the p38 MAPK, a member of the MAPK superfamily, cascade in hepatoma cell lines and in human hepatocellular carcinoma