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Involvement of nitric oxide in Parkinson's disease: Emphasis on sex difference in prevalence

✍ Scribed by Dilek Taskiran; Bijen Nazliel; Ceyla Irkec; Fatma Z. Kutay; Sakire Pogun

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
941 KB
Volume
32
Category
Article
ISSN
0893-6609

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Parkinson's disease (PD) is characterized by severe movement disorders. Excessive production of reactive oxygen species has been implicated as a possible mediator of neurodegenerative changes in nigrostriatal neurons in PD. Nitric oxide (NO) has received substantial attention among pathophysiological factors underlying glutamate neurotoxicity in neurodegenerative disorders including PD. PD is more prevalent in men than in women by an approximate 3:2 ratio; the nitrergic systems are also more active in males than females. In this study, NO~2~^−^+NO~3~^−^ (stable metabolites of NO) levels were determined in sera of PD patients (n=20) and control subjects (n=16). NO~2~^−^+NO~3~^−^ Levels were higher in PD patients compared to controls, and in males compared to females. Furthermore, there was a correlation between age and NO metabolites in females but not in males. These data support a role for NO in PD and provide further evidence for sex differences in NO activity that may underlie neurodegenerative disorders.

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