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Involvement of NADPH: cytochrome P450 reductase in the activation of indoloquinone EO9 to free radical and DNA damaging species

✍ Scribed by Susan M. Bailey; Alex D. Lewis; Laurence H. Patterson; Geoff R. Fisher; Richard J. Knox; Paul Workman


Book ID
113992706
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
367 KB
Volume
62
Category
Article
ISSN
0006-2952

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The concept of relative activity factor (RAF) to extrapolate data obtained with recombinant cytochrome P450(CYP)s to human liver microsomes has been proposed. To evaluate the approach to predict the contribution of multiple CYPs using RAF, we investigated the effects of the differences in the expres