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Involvement of Multidrug Resistance-Associated Protein 1 in Intestinal Toxicity of Methotrexate

✍ Scribed by Sayaka Kato; Katsuaki Ito; Yukio Kato; Tomohiko Wakayama; Yoshiyuki Kubo; Shoichi Iseki; Akira Tsuji


Publisher
Springer US
Year
2009
Tongue
English
Weight
399 KB
Volume
26
Category
Article
ISSN
0724-8741

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Cellular resistance to methotrexate (MTX) is believed to be unaffected by expression of MDRl P-glycoprotein (Pgp), a pleiotropic efflux pump acting on different hydrophobic compounds that enter cells by passive diffusion. A series of human leukemic CCRF-CEM sublines, isolated by multi-step selection