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Involvement of morbilliviruses in the pathogenesis of demyelinating disease

✍ Scribed by G. J. Sips; D. Chesik; L. Glazenburg; J. Wilschut; J. De Keyser; N. Wilczak

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
599 KB
Volume
17
Category
Article
ISSN
1052-9276

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✦ Synopsis

Abstract

Two members of the morbillivirus genus of the family Paramyxoviridae, canine distemper virus (CDV) and measles virus (MV), are well‐known for their ability to cause a chronic demyelinating disease of the CNS in their natural hosts, dogs and humans, respectively. Both viruses have been studied for their potential involvement in the neuropathogenesis of the human demyelinating disease multiple sclerosis (MS). Recently, three new members of the morbillivirus genus, phocine distemper virus (PDV), porpoise morbillivirus (PMV) and dolphin morbillivirus (DMV), have been discovered. These viruses have also been shown to induce multifocal demyelinating disease in infected animals. This review focuses on morbillivirus‐induced neuropathologies with emphasis on aetiopathogenesis of CNS demyelination. The possible involvement of a morbillivirus in the pathogenesis of multiple sclerosis is discussed. Copyright Β© 2007 John Wiley & Sons, Ltd.

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