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Involvement of mitochondria in acetaminophen-induced apoptosis and hepatic injury: Roles of cytochrome c, Bax, Bid, and caspases

✍ Scribed by Hasan El-Hassan; Khurshid Anwar; Patricia Macanas-Pirard; Mark Crabtree; Sek C Chow; Victoria L Johnson; Pauline C Lee; Richard H Hinton; Shirley C Price; George E.N Kass

Book ID
114087142
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
575 KB
Volume
191
Category
Article
ISSN
0041-008X

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## Abstract The c‐Myc transcription factor is a key regulator of cell proliferation, differentiation, and apoptosis. While deregulation of myc induces programmed cell death, defects in the apoptotic program facilitate Myc‐driven tumor development. We have treated c‐Myc inducible mouse cells and rat