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Involvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases in gastric carcinoma cells

โœ Scribed by Hiroshi Yasuda; Shuko Hirata; Kazuaki Inoue; Hirosato Mashima; Hirohide Ohnishi; Makoto Yoshiba

Book ID
116294220
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
288 KB
Volume
354
Category
Article
ISSN
0006-291X

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The G-Protein-coupled bile acid receptor
The G-Protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-ฮบB) in mice
โœ Yan-Dong Wang; Wei-Dong Chen; Donna Yu; Barry M. Forman; Wendong Huang ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 934 KB

Gpbar1 (TGR5), a membrane-bound bile acid receptor, is well known for its roles in regulation of energy homeostasis and glucose metabolism. TGR5 also displays strong attenuation of macrophage reactivity in vitro, but the physiological roles of TGR5 in inflammatory response, and its mechanism, is unk