Involvement of matrix metalloproteinase 2 and 9 in gambogic acid induced suppression of MDA-MB-435 human breast carcinoma cell lung metastasis

Suppression of distant pulmonary metasta

Suppression of distant pulmonary metastasis of MDA-MB 435 human breast carcinoma established in mammary fat pads of nude mice by retroviral-mediated TIMP-2 gene transfer

✍ Young-Kwan Lee; In-Seob So; Sang-Chul Lee; Jeong-Hyung Lee; Chang-Woo Lee; Whan- 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 482 KB

Background Previous studies have shown that TIMP-2 overexpression is a useful therapeutic tool for inhibiting tumor growth and invasion in animals. However, it has not been reported whether genetic manipulation for TIMP-2 overexpression can induce an inhibitory effect on spontaneous metastasis from