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Involvement of kappa opioid receptors in the inhibition of receptor desensitization and PKC activation induced by repeated morphine treatment

✍ Scribed by Wakako Hamabe; Hiroyuki Yamane; Shinichi Harada; Shogo Tokuyama

Book ID: 111770877
Publisher: Pharmaceutical Press
Year: 2008
Tongue: English
Weight: 415 KB
Volume: 60
Category: Article
ISSN: 2042-7158
DOI: 10.1211/jpp.60.9.0010

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There is strong evidence supporting the existence of multiple kappa receptors. Previous studies proposed that U69,593 and (ϩ)-tifluadom act on different kappa receptor subtypes, kappa 1 ( 1 ) and kappa 2 ( 2 ), respectively. In this study, we investigated the effects of the kappa selective antagonis