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Involvement of interleukin 1 and interleukin 1 antagonist in pancreatic β-cell destruction in insulin-dependent diabetes mellitus

✍ Scribed by Thomas Mandrup-Poulsen; Urs Zumsteg; Jesper Reimers; Flemming Pociot; Lise Mørch; Steffen Helqvist; Charles A. Dinarello; Jørn Nerup

Book ID
116172429
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
793 KB
Volume
5
Category
Article
ISSN
1043-4666

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✍ Iain L. Campbell; Leonard C. Harrison 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 572 KB

Insulin-dependent (type 1) diabetes mellitus (IDDM) is due to the selective autoimmune-mediated destruction of pancreatic beta cells possibly initiated by viruses. To elucidate the possible role of viruses and cytokines in the pathogenesis of IDDM, we have examined the effect of reovirus infection o