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Involvement of Hrs Binding Protein in IgE Receptor-Triggered Exocytosis in RBL-2H3 Mast Cells

✍ Scribed by Sachiko Murai; Naomi Kitamura


Book ID
115586829
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
165 KB
Volume
277
Category
Article
ISSN
0006-291X

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In RBL-2H3 rat leukemic mast cells, cross-linking anti-DNP IgE-receptor complexes with multivalent antigen (DNP-BSA) activates a signal transduction pathway leading to Ca2+ influx and secretion. Cross-linking IgE-receptor complexes also stimulates a pathway that inactivates (desensitizes) receptors;