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Involvement of hepatic xenobiotic related genes in bromadiolone resistance in wild Norway rats, Rattus norvegicus (Berk.)

✍ Scribed by Mette Drude Markussen; Ann-Charlotte Heiberg; Carsten Alsbo; Peter Stein Nielsen; Sakari Kauppinen; Michael Kristensen


Book ID
113844796
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
253 KB
Volume
88
Category
Article
ISSN
0048-3575

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Characterization of bromadiolone resista
✍ Mette Drude Markussen; Ann-Charlotte Heiberg; Merete Fredholm; Michael Kristense πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 222 KB

## Abstract The present study characterizes the anticoagulant resistance mechanism in a Danish bromadiolone‐resistant strain of Norway rats (__Rattus norvegicus__), with a Y139C VKORC1 mutation. We compared liver expression of the VKORC1 gene, which encodes a protein of the vitamin K 2,3‐epoxide re