Involvement of Heat Shock Proteins in the Phenomenon of Cell Protection against Apoptosis Mediated by Inhibitors of Plasma Membrane Chlorine Channels

Involvement of calcium in the differenti

Involvement of calcium in the differential induction of heat shock protein 70 by heat shock protein 90 inhibitors, geldanamycin and radicicol, in human non-small cell lung cancer H460 cells

✍ Yuo-Sheng Chang; Lee-Chen Lee; Fang-Chun Sun; Chih-Chung Chao; Hua-Wen Fu; Yiu-K 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 269 KB 👁 2 views

Both geldanamycin (GA) and radicicol (RA) are HSP90 binding agents that possess antitumour activities. Although the in vitro data indicated that the inhibitory constant of RA is much bigger than that of GA, the in vivo data on drug efficacy might reveal different results. We have recently shown that