Involvement of ERK1/2, p38 and PI3K in megakaryocytic differentiation of K562 cells
✍ Scribed by Isabel Conde; Dina Pabón; Asier Jayo; Pedro Lastres; Consuelo González-Manchón
- Book ID
- 114794741
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 556 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0902-4441
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract We studied the effects of cyclosporin A (CsA) on the erythroid differentiation of human erythroid leukemia cell line K562. After K562 was treated with CsA for 4 days, the percentage of hemoglobinized cells was increased by 3.3 times. Because it was reported p38 MAPK (p38) and ERK are in
## Abstract STI571 is a specific tyrosine kinase inhibitor of Abl kinase. It was previously reported that STI571 induced hemoglobin synthesis in the chronic myelogenous leukemia (CML) cell line K562. However, its mechanisms remain unknown. In this study, we demonstrated that STI571 induced the phos