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Involvement of endothelin/ nitric oxide balance in hepatic ischemia/ reperfusion injury

✍ Scribed by S. Scommotau; Dirk Uhlmann; Bernd-Michael Löffler; Volker Breu; Hans-Ullrich Spiegel


Publisher
Springer
Year
1999
Tongue
English
Weight
215 KB
Volume
384
Category
Article
ISSN
1435-2451

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We determined the functional role of nitric oxide (NO) and endothelins (ET), two potent vasoactive mediator systems in the liver, for the pathogenesis of sinusoidal perfusion failure and lethal hepatocyte injury after low-flow ischemia/reperfusion in the isolated perfused rat liver. NO synthase bloc