## Abstract Microglial activation is believed to play a pivotal role in the selective neuronal injury associated with several neurodegenerative disorders, including Parkinson's disease (PD) and Alzheimer's disease. We provide evidence that (β)βepigallocatechin gallate (EGCG), a major monomer of gre
β¦ LIBER β¦
Involvement of dopaminergic neuronal cystatin C in neuronal injury-induced microglial activation and neurotoxicity
β Scribed by Garima Dutta; David S. Barber; Ping Zhang; Nicholas J. Doperalski; Bin Liu
- Book ID
- 115270873
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 576 KB
- Volume
- 122
- Category
- Article
- ISSN
- 0022-3042
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## Abstract We have shown that prothrombin kringleβ2 (pKrβ2), a domain of human prothrombin distinct from thrombin could activate cultured rat brain microglia in vitro. However, little is known whether pKrβ2βinduced microglial activation could cause neurotoxicity on dopaminergic (DA) neurons in viv