## Abstract Dโserine is an endogenous NโmethylโDโaspartate (NMDA) receptor coagonist. It is synthesized from Lโserine by serine racemase (SRR), but many aspects of its metabolism remain unclear, especially in the forebrain, which lacks active Dโamino acid oxidase (DAO), the major Dโserine degradati
Involvement of D-amino acid oxidase in elimination of D-serine in mouse brain
โ Scribed by Y. Nagata
- Publisher
- Springer
- Year
- 1992
- Tongue
- English
- Weight
- 306 KB
- Volume
- 48
- Category
- Article
- ISSN
- 1420-682X
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## Abstract In the brain, the human flavoprotein Dโamino acid oxidase (hDAAO) is involved in the degradation of the gliotransmitter Dโserine, an important modulator of NMDAโreceptorโmediated neurotransmission; an increase in hDAAO activity (that yields a decrease in Dโserine concentration) was rece