## Abstract The c‐Myc transcription factor is a key regulator of cell proliferation, differentiation, and apoptosis. While deregulation of myc induces programmed cell death, defects in the apoptotic program facilitate Myc‐driven tumor development. We have treated c‐Myc inducible mouse cells and rat
✦ LIBER ✦
Involvement of CPP32/Caspase-3 in c-Myc-induced apoptosis
✍ Scribed by Kangas, Anneli; Nicholson, Donald W; Hölttä, Erkki
- Book ID
- 110061299
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 473 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0950-9232
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Recent studies indicate that arsenic may generate reactive oxygen species to exert its toxicity. However, the mechanism is still unclear. In this study, we demonstrate that arsenite is able to induce apoptosis in a concentration-and time-dependent manner; however, arsenate is unable to do so. An inc