Zygotic gene activation (ZGA) is the critical event that governs the transition from maternal to embryonic control of development. In the mouse, ZGA occurs during the 2-cell stage and appears to be regulated by the time following fertilization, i.e. a zygotic clock, rather than by progression throug
Involvement of chromatin structure in the regulation of mouse zygotic gene activation
β Scribed by Tasuku CHO; Senkiti SAKAI; Masao NAGATA; Fugaku AOKI
- Book ID
- 111666658
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 263 KB
- Volume
- 73
- Category
- Article
- ISSN
- 1344-3941
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## Abstract Protein phosphorylation catalyzed by the cyclic adenosine monophosphate (cAMP)βdependent protein kinase (PKA) is implicated in regulating zygotic gene activation in the twoβcell mouse embryo (Poueymirou and Schultz; Dev Biol 133:588β599, 1989). We now provide evidence that H8, which is