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Involvement of c-jun N-terminal kinase in G2/M arrest and caspase-mediated apoptosis induced by cardiotoxin III (Naja naja atra) in K562 leukemia cells

โœ Scribed by Sheng-Huei Yang; Ching-Ming Chien; Long-Sen Chang; Shinne-Ren Lin

Book ID
116921751
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
323 KB
Volume
49
Category
Article
ISSN
0041-0101

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Involvement of c-Jun N-terminal kinase i
Involvement of c-Jun N-terminal kinase in G2/M arrest and FasL-mediated apoptosis induced by a novel indoloquinoline derivative, IQDMA, in K562 cells
โœ Sheng-Huei Yang; Ching-Ming Chien; Chih-Ming Lu; Yeh-Long Chen; Long-Sen Chang; ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 511 KB

N'-(11H-Indolo[3,2-c]quinolin-6-yl)-N,N-dimethylethane-1,2-diamine (IQDMA), an indoloquinoline derivative, synthesized in our laboratory, has been demonstrated to be an effective anti-tumor agent in human leukemia cells. Treatment of K562 cells with IQDMA resulted in G2/M phase cell cycle arrest, pr