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Involvement of both tumor necrosis factor-α-induced necrosis and p53-mediated caspase-dependent apoptosis in nephrotoxicity of cisplatin

✍ Scribed by Takahisa Yano; Yoshinori Itoh; Misaki Matsuo; Takehiro Kawashiri; Nobuaki Egashira; Ryozo Oishi

Publisher: Springer
Year: 2007
Tongue: English
Weight: 404 KB
Volume: 12
Category: Article
ISSN: 1360-8185
DOI: 10.1007/s10495-007-0110-8

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## Apoptosis is induced in cells via distinct pathways, which may differ according to various stimuli and different cell types. One apoptotic stimulus is the activation of receptors such as the p55 tumor necrosis factor (TNF) receptor. These receptors transduce their apoptotic signals via a cytopl