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Involvement of APO2 ligand/TRAIL in activation-induced death of Jurkat and human peripheral blood T cells

✍ Scribed by María José Martínez-Lorenzo; Maria A. Alava; Susana Gamen; K. Jin Kim; Anan Chuntharapai; Andrés Piñeiro; Javier Naval; Alberto Anel


Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
193 KB
Volume
28
Category
Article
ISSN
0014-2980

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Surface expression of TRAIL/Apo-2 ligand
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Like other members of the TNF family, TRAIL/Apo-2 ligand induces apoptosis in sensitive target cells in a caspase-dependent fashion. We recently found that TRAIL may be constitutively expressed on the surface of mouse and human tumor cells of T and B origin. To define the pattern of TRAIL expression