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Involvement of angiotensin-converting enzyme inhibition in reversal of helpless behavior evoked by perindopril in rats

✍ Scribed by Patrick Martin; Jacques Massol; Elizabeth Scalbert; Alain J. Puech

Book ID
115882908
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
416 KB
Volume
187
Category
Article
ISSN
0014-2999

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Lisinopril is a potent competitive inhibitor of purified rabbit lung ACE (dissociation t1/2 = 105 min). To examine reversibility of binding and ACE functional activity in situ, the single-pass extraction (E) of an 125I-lisinopril analogue (351A) and the hydrolysis of an ACE substrate, benz-phe-ala-p