Involvement of Akt kinase in the action of STI571 on chronic myelogenous leukemia cells
β Scribed by Kiyotaka Kawauchi; Toshie Ogasawara; Masako Yasuyama; Shin-ichiro Ohkawa
- Book ID
- 117726524
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 330 KB
- Volume
- 31
- Category
- Article
- ISSN
- 1079-9796
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## Abstract ## BACKGROUND Chronic myelogenous leukemia (CML) is characterized by a molecular aberration, a fusion __BCRβABL__ gene encoding for aberrant tyrosine kinase activity, which is crucial in the pathogenesis of CML. In vitro, inhibition of BCRβABL protein tyrosine kinase activity by a tyro
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