## Abstract Demyelination is a common result of oxidative stress in the nervous system, and we report here that the response of oligodendrocytes to oxidative stress involves the receptor for advanced glycation end products (RAGE). RAGE has not previously been reported in neonatal rat oligodendrocyt
Involvement of advanced glycation end products, oxidative stress and nuclear factor-kappaB in the development of diabetic keratopathy
β Scribed by Junghyun Kim; Chan-Sik Kim; Eunjin Sohn; Il-Ha Jeong; Hyojun Kim; Jin Sook Kim
- Publisher
- Springer-Verlag
- Year
- 2010
- Tongue
- English
- Weight
- 335 KB
- Volume
- 249
- Category
- Article
- ISSN
- 0065-6100
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Advanced glycation end products (AGE) and dicarbonyl compounds accumulate in serum and tissues of patients with diabetes and chronic renal failure. Pentosidine, free pentosidine, glyoxal and methylglyoxal have been evaluated in plasma of diabetic patients with poor metabolic control at baseline and
## Abstract ## Background Hyperglycaemia induces nonβenzymatic glycation reactions in proteins which generate Amadori products and advanced glycation endβproducts; the latter are thought to participate in the vascular complications of diabetic patients. However, the exact mechanisms concerning the