Involvement of activation of Toll-like receptors and nucleotide-binding oligomerization domain–like receptors in enhanced IgG4 responses in autoimmune pancreatitis

Enhanced antigen-specific primary CD4+ a

Enhanced antigen-specific primary CD4+ and CD8+ responses by codelivery of ovalbumin and toll-like receptor ligand monophosphoryl lipid A in poly(D,L-lactic-co-glycolic acid) nanoparticles

✍ Samar Hamdy; Praveen Elamanchili; Aws Alshamsan; Ommoleila Molavi; Tadaaki Satou 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 609 KB

## Abstract The purpose of this research was to investigate the use of biodegradable poly(D,L‐lactic‐__co__‐glycolic acid) nanoparticles (PLGA‐NP) as a vaccine delivery system to codeliver antigen, ovalbumin (OVA) along with monophosphoryl lipid A (MPLA) as adjuvant for induction of potent CD4^+^ a