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Involvement of a serine protease, but not of neutrophil elastase, in tumor necrosis factor-induced lethal hepatitis and induction of platelet-activating factor

โœ Scribed by Ben Wielockx; Federico Bussolino; Steven D. Shapiro; Claude Libert


Book ID
119526672
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
374 KB
Volume
35
Category
Article
ISSN
0168-8278

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Fas receptor and tumor necrosis factor receptor-1 (TNFR1) mediate the activation of acid sphingomyelinase (ASMase), which catalyzes the hydrolysis of sphingomyelin to ceramide. Ceramide acts as a second messenger in mediating cell growth, differentiation, stress response, and apoptosis. Ultraviolet