✦ LIBER ✦
INVOLUTION OF MOUSE MAMMARY GLANDS DURING WHOLE ORGAN CULTURE OCCURS VIA APOPTOSIS OF EPITHELIAL TISSUE
✍ Scribed by T.M. CASEY; H. CHEN; K. PLAUT; J.F. CHIU
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 867 KB
- Volume
- 20
- Category
- Article
- ISSN
- 1065-6995
No coin nor oath required. For personal study only.
✦ Synopsis
Apoptosis was measured in mammary glands during whole organ culture, to determine whether regression resulting from hormone withdrawal results in epithelial cell death as in vivo involution. Glands were evaluated for morphology and DNA degradation prior to whole organ culture, after lobulo-alveolar development and 2, 4, or 6 days after hormone withdrawal. The data indicated that mammary regression during whole organ culture mimics in vivo involution and results in part from apoptosis of epithelial tissue.