Invited contribution: An objective approach to the development of short-term tests predictive of carcinogenicity

✍ Scribed by Herbert S. Rosenkranz; Fanny K. Ennever; Vira Chankong; Julia Pet-Edwards; Yacov Y. Haimes

• Publisher: Springer
• Year: 1986
• Tongue: English
• Weight: 836 KB
• Volume: 2
• Category: Article
• ISSN: 0742-2091
• DOI: 10.1007/bf00117846

✦ Synopsis

The Carcinogenicity Prediction and Battery Selection procedure was developed to address two problems: (1) the identification of highly predictive, yet cost-effective, batteries of short-term tests and ( 2) the objective prediction of the potential carcinogenicity of chemicals based upon the results of short-term tests even when a mixture of positive and negative results is obtained. In the present report the usefulness of the Carcinogenicity Prediction and Battery Selection procedure is demonstrated using benzo[aj~yrene, benzoin and diethylstilbestrol as examples. In addition, its applicability in the analysis of all the possible outcomes of a battery is illustrated together with an analysis of the worth of additional testing.