Invited. Calibration of water proton chemical shift with temperature for noninvasive temperature imaging during focused ultrasound surgery
✍ Scribed by Kagayaki Kuroda; Andrew H. Chung; Kullervo Hynynen; Ferenc A. Jolesz
- Book ID
- 102905578
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 990 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1053-1807
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✦ Synopsis
The present work was performed to calibrate water proton chemical shift change with tissue temperature in vivo to establish a method of quantitative temperature imaging during focused ultrasound surgery. The chemical shift change measured with a phase-mapping method using spoiled gradient-recalled acquisition in steady state (SPGR) (TR = 26 msec, TE = 12.8 msec, matrix = 256 x 128) was calibrated with the corresponding temperature elevation (0-50 degrees C, 32-84 degrees C in absolute temperature) measured with a copper-constantan thermocouple (.05-mm-diameter bare wires) in rabbit skeletal muscle (16 animals) under focused ultrasound exposures (10-100 W radiofrequency [RF] power, 20-second sonication). A linear calibration with a regression coefficient of (-8.76+/-.69) x 10(-3) ppm/degrees C (P < .01 [P, significance level]) was obtained. Temperature distributions during a 20-second sonication were visualized every 3.3 seconds with a 2.3-mm3 spatial resolution and 4 degrees C temperature uncertainty.