Investigations on sterols XXI: An alternative route for the synthesis of some 6-dehydro-9β,10α-steroid hormone analogues

✍ Scribed by A. Smit; P. Westerhof

• Publisher: Elsevier Science
• Year: 2010
• Tongue: English
• Weight: 362 KB
• Volume: 82
• Category: Article
• ISSN: 0165-0513
• DOI: 10.1002/recl.19630821115

✦ Synopsis

Abstract

Selective ozonisation of isolumisterone produced 9β,10α‐bisnorchola‐4,6‐dien‐3‐on‐22‐al. This compound could be converted into: 6‐dehydro‐9β,10α‐progesterone (9β,10α‐pregna‐4,6‐diene‐3,20‐dione); 6‐dehydro‐17α‐hydroxy‐9β,10α‐progesterone (9β,10α‐pregna‐4,6‐dien‐17α‐ol‐3,20‐dione) and 6‐dehydro‐9β,10α‐testosterone (9β,10α‐androsta‐4,6‐dien‐17β‐ol‐3‐one).