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Investigations on metabolism of zearalenone in broilers

✍ Scribed by S Dänicke; K-H Ueberschär; I Halle; H Valenta

Publisher
Springer-Verlag
Year
2000
Tongue
English
Weight
227 KB
Volume
16
Category
Article
ISSN
0178-7888

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Aromatic hydroxylation is a major metabo
Aromatic hydroxylation is a major metabolic pathway of the mycotoxin zearalenone in vitro
✍ Erika Pfeiffer; Andreas Hildebrand; Georg Damm; Andreas Rapp; Benedikt Cramer; H 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 869 KB

## Abstract Zearalenone (ZEN) is a common mycotoxin, for which only reductive metabolites have been identified so far. We now report that ZEN is extensively monohydroxylated by microsomes from human liver __in vitro__. Two of the major oxidative metabolites arise through aromatic hydroxylation and