Investigations of animal blood samples after fragrance drug inhalation by gas chromatography/mass spectrometry with chemical ionization and selected ion monitoring

✍ Scribed by L. Jirovetz; W. Jäger; G. Buchbauer; A. Nikiforov; V. Raverdinno

• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 164 KB
• Volume: 20
• Category: Article
• ISSN: 1076-5174
• DOI: 10.1002/bms.1200201210

✦ Synopsis

The fragrance compounds linalool(1) and linalyl acetate (2) could be detected, identified and quantified (1: 7-9 ng ml-'; and 2: 1-2 ng ml-' and 4-5 ng ml-' as free linalool) in blood samples after inhalation in animal experiments (mice) by gas chromatography/mass spectrometry (CC/MS) with chemical ionization (CI) (ammonia); selected ion monitoring (SIM) mode (1: m/z 81, 137 and 154; 2: 47, 57 and 137) and GC/flame ionization detection (FID). The inhalation of these monoterpenes in concentrations of 5 mg I-' air leads to a significant reduction of the motility of the test animals down to 3040% with respect to the control group.