Investigations into the mechanisms of carcinogen-induced nuclear enlargement in HeLa S3 cells in vitro
โ Scribed by C. Westmoreland; D.J. Benford; L.J. Eales; P. Grasso
- Book ID
- 116152982
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 909 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0887-2333
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In this study we investigated the effect of heat on the proteins of the particulate fraction (PFj of HeLa S3 cells using electron spin resonance (ESRj and thermal gel analysis (TCA). ESR detects overall conformational changes in proteins, while TG.4 detects denaturation (aggregation due to formation
## Abstract Cumulating evidence has led to the idea that nuclear functions such as DNA replication, RNA transcription, RNA splicing and nucleocytoplasmic transport are facilitated by a proteinaceous architectural framework within the nuclear compartment and at the nuclear envelope. In the present s