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Investigation on Genetic Heterogeneity of α-Subunit of the Epithelial Sodium Channel in Rat Renal Cortex

✍ Scribed by N. S. Logvinenko; Y. E. Herbeck; L. N. Ivanova


Publisher
Springer US
Year
2011
Tongue
English
Weight
524 KB
Volume
151
Category
Article
ISSN
0007-4888

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The present study evaluated the effects of the anti-emetic 5-HT3 antagonist dolasetron and its major metabolite MDL 73,405 on guinea-pig papillary muscle fibres and human heart sodium channels expressed in Xenopus oocytes. Dolasetron and MDL 73,405 (3-10 p M ) reduced the maximum depolarization rate