𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Investigation of the utility of published in vitro intrinsic clearance data for prediction of in vivo clearance

✍ Scribed by Rakesh Nagilla; Kelly A. Frank; Larry J. Jolivette; Keith W. Ward

Book ID
113941132
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
329 KB
Volume
53
Category
Article
ISSN
1056-8719

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Predicting the hepatic clearance of xeno
Predicting the hepatic clearance of xenobiotics in humans from in vitro data
✍ Betty-Ann Hoener πŸ“‚ Article πŸ“… 1994 πŸ› John Wiley and Sons 🌐 English βš– 449 KB

Values for V,, and K, determined during the in vitro metabolism of a xenobiotic to a known metabolite by a specific human isozyme of cytochrome P450 (P450) were used to predict the hepatic clearance (CLH) of the xenobiotic to that metabolite. The calculated CLH values were then compared to literatur