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Investigation of the solubility relationships of polar, semi-polar and non-polar drugs in mixed co-solvent systems

โœ Scribed by Gould, Philip L.; Goodman, Michael; Hanson, Paul A.


Book ID
121244926
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
671 KB
Volume
19
Category
Article
ISSN
0378-5173

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๐Ÿ“œ SIMILAR VOLUMES


Solubility of nonelectrolytes in polar s
โœ S. H. Yalkowsky; S. C. Valvani; G. L. Amidon ๐Ÿ“‚ Article ๐Ÿ“… 1976 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 758 KB

The molecular and group surface area approach to solubility is shown to be applicable to mixed aqueous solvent systems. An equation is derived which is consistent with the exponential increase in the aqueous solubility of nonpolar drugs that frequently accompanies the addition of a cosolvent. This e