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Investigation of the role of Ras and other signaling kinases on the regulation of pyruvate dehydrogenase complex activity

โœ Scribed by Garcia-Trinidad, Antonio; Whalley, Nicky; Critchlow, Susan

Book ID
125404849
Publisher
BioMed Central
Year
2014
Tongue
English
Weight
83 KB
Volume
2
Category
Article
ISSN
2049-3002

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## Abstract Activating __ras__ mutations are frequently found in malignant tumors of the pancreas, colon, lung and other tissues. RAS activates a number of downstream pathways that ultimately cause cellular transformation. Several recent studies suggested that one of those pathways involves Aurora