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Investigation of the regulatory role of heme oxygenase-1 and its products in VEGF-mediated angiogenesis

✍ Scribed by Andrea Bauer; Catherine C. Thornton; Hayley Mylroie; Graeme M. Birdsey; Dorian O. Haskard; Anna M. Randi; Justin C. Mason


Book ID
113952184
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
127 KB
Volume
56
Category
Article
ISSN
1537-1891

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## Abstract Arsenite, an environmental cocontaminant of polycyclic aromatic hydrocarbons (PAHs), diminishes the PAH‐mediated upregulation of human CYP1A1, the enzyme that bioactivates PAHs to carcinogenic metabolites. Mechanistically, while transcriptional downregulation contributes to these effect