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Investigation of the PDZ domain ligand binding site using chemically modified peptides

✍ Scribed by Kathleen A.P Novak; Naoaki Fujii; R.Kiplin Guy

Book ID
108477249
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
118 KB
Volume
12
Category
Article
ISSN
0960-894X

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## Abstract Grb7 is a member of the Grb7 family of proteins, which also includes Grb10 and Grb14. All three proteins have been found to be overexpressed in certain cancers and cancer cell lines. In particular, Grb7 (along with the receptor tyrosine kinase erbB2) is overexpressed in 20–30% of breast