✦ LIBER ✦

Investigation of the Mode of Action of Nematode Neuropeptides

✍ Scribed by Keating, Christopher D.; Holden-Dye, Lindy M.; Walker, Robert J.

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 277 KB
Volume: 46
Category: Article
ISSN: 1526-498X
DOI: 10.1002/(sici)1096-9063(199603)46:3<263::aid-ps346>3.0.co;2-u

No coin nor oath required. For personal study only.

✦ Synopsis

The neuropeptide AF2 has a complex set of actions on the dorsal muscle strip of Ascaris mum, including a potentiation of the acetylcholinestimulated muscle contraction. Caffeine at 100 PM and 5 mM inhibited this potentiation, as did 100 PM theophylline in two out of six studies. The cyclic-AMPpotentiating compounds IBMX, dibutyryl cAMP and forskolin had no effect on the AF2-induced potentiation of the acetylcholine-stimulated muscle contraction. These preliminary data suggest that the potentiating action of AF2 is not mediated by a cAMP pathway.

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