๐”– Bobbio Scriptorium
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Investigation of the mechanism of cadmium toxicity at cellular level

โœ Scribed by A. F. W. Morselt; J. H. J. Copuis Peereboom-Stegeman; E. J. Jongstra-Spaapen; J. James


Publisher
Springer-Verlag
Year
1983
Tongue
English
Weight
640 KB
Volume
52
Category
Article
ISSN
0340-5761

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โœฆ Synopsis


Chromatin condensation occurs within 15 min to 1 h after the addition of CdC12 in a concentration of 1 ~tg/ml to a liver cell culture and seems to be the first event demonstrable by light microscopy.

This chromatin condensation, which precedes membrane leakage, is irreversible and leads to cell death of almost all cells. It does not occur after the administration of equimolecular concentrations of some other bivalent metallic ions.


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The interacting effects of cadmium toxicity and food limitation on the midge, Chironomus riparius, were studied during chronic exposure in laboratory experiments. If the food was supplied ad libitum, both larval developmental time and mortality of the larvae were negatively affected by cadmium conce