Investigation of the mass-spectrometric fragmentation of some isoindole derivatives

✍ Scribed by P. B. Terent'ev; V. A. Kovtunenko; Z. V. Voitenko; T. T. Kucherenko; V. V. Ishchenko; A. K. Tyltin; F. S. Babichev

• Publisher: Springer US
• Year: 1991
• Tongue: English
• Weight: 362 KB
• Volume: 27
• Category: Article
• ISSN: 0009-3122
• DOI: 10.1007/bf00476203

✦ Synopsis

The results of a mass-spectrometric investigation of isoindole derivatives have made it possible m ascertain specific pathways in their fragmentation that differ from those for analogous indole derivatives and to also confirm the previously advanced concept regarding the structures of isoindoles, which have a complete 107r-electron system with substantial interannular conjugation.

A number of isoindole derivatives have high biological activity [ 1,2]. Mass spectrometry and chromatographic mass spectrometry have recently begun to be used extensively to identify physiologically active compounds in natural substances; this, in turn, requires a knowledge of the character of the fragmentation of these substances under electron impact [3,4]. At the same time, as already noted in [1], the mass-spectral behavior of isoindole derivatives has been studied extremely inadequately. This compelled us to examine the principal fragmentation pathways of isoindoles I-VIII, the synthesis of which was described in [5][6][7][8][9][10].