The human GNAI2 gene coding for G protein, Gai2, is located on chromosome 3p21 in proximity to the region where an inflammatory bowel disease (IBD) locus has been suggested. Gai2-deficient mice develop a lethal diffuse colitis that resembles human ulcerative colitis (UC) and frequently progresses to
✦ LIBER ✦
Investigation of the GNAI2 gene in inflammatory bowel disease
✍ Scribed by Satsangi, J.; D’Echairo, B.; Carey, A.; Lench, N.; van Heel, D.; Edwards, M.; Jewell, D.P.
- Book ID
- 122098274
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 161 KB
- Volume
- 118
- Category
- Article
- ISSN
- 0016-5085
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## Background: The pregnane X receptor gene (PXR/NR1I2) has been recently associated with an increased risk for inflammatory bowel disease (IBD), although a subsequent case-control study failed to replicate the original association in an independent population. This nuclear receptor regulates gene