Functional roles for amino acids in acti
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Francisco J Medrano; Mary A Wenck; Ann E Eakin; Sydney P Craig III
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Article
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2003
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Elsevier Science
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English
β 350 KB
A flexible loop of amino acids (loop II) closes over the active site of hypoxanthine phosphoribosyltransferase (HPRT) as the enzyme approaches the transition state [Biochemistry 37 (1998) 17120]. Formerly, the deletion of much of loop II from the HPRT of Trypanosoma cruzi resulted in a 2-3 order of