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Investigation of the dynamics of cyclodextrins and their inclusion complexes in water by deuterium NMR

✍ Scribed by Nathalie Azaroual-Bellanger; Bruno Perly

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
402 KB
Volume
32
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

Deuterium NMR and relaxation data are presented to investigate the state of β‐cyclodextrin in aqueous solution and to derive dynamic parameters for inclusion complexes. Labelled host and guest molecules were used, and dedicated pulse sequences are proposed for improving the deuterium spectra in terms of reduction of artifacts and of solvent peak(s) and also in terms of total duration of the experiments. This technique was used to investigate the state of β‐cyclodextrin in aqueous solution and to derive important information regarding the degree of dynamic coupling between host and guest in inclusion complexes.

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