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Investigation of the Chemical Stability of a New Growth Hormone—Releasing Hormone (GHRH) Analogue by HPLC

✍ Scribed by M. Idei; I. Mezö; E. Z. Szabó; Gy. Kéri


Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
239 KB
Volume
10
Category
Article
ISSN
0269-3879

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✦ Synopsis


The stability of a new active growth hormonereleasing hormone analogue (~-Ala*,Nle", (gamma-amino-butyric acid)s-GHRH(1-30)-NH3 was investigated during storage at different temperatures in aqueous solution. Samples stored for various periods of time were analysed by HPLC. It is concluded that in aqueous solution D-Ala*,Nlen, (gamma-amino-butyric acid)'"-growth hormone-releasing hormone (l-30)-NH2 is stable: at least for 36 days at 4°C; for 28 days at 25°C; and for 10 days at 37°C.