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Investigation of Synthetic Routes to a Key Benzopyran Intermediate of a 5HT4 Agonist

โœ Scribed by Rassias, Geracimos; Stevenson, Neil G.; Curtis, Neil R.; Northall, John M.; Gray, Matthew; Prodger, Jeremy C.; Walker, Andrew J.


Book ID
115465183
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
309 KB
Volume
14
Category
Article
ISSN
1083-6160

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This Letter describes the synthetic challenges in synthesising key 1,4-cis-substituted cyclohexylamide intermediate 1 for our research programme. Five different routes address the major issues of selectivity to afford the cis product in isomerically pure form and in high yield. Major purification is