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Investigation of Structural Changes Upon Ligand Binding of the Methylated Neuropeptide Y Receptor Type 2

✍ Scribed by Berndt, Sandra; Schmidt, Peter; Berger, Christian; Beck-Sickinger, Annette; Huster, Daniel


Book ID
119207965
Publisher
Biophysical Society
Year
2011
Tongue
English
Weight
48 KB
Volume
100
Category
Article
ISSN
0006-3495

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Changes in structural dynamics of the Gr
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Growth factor receptor-bound protein 2 (Grb2) is an extensively studied adaptor protein involved in cell signaling. Grb2 is a highly flexible protein composed of a single SH2 domain flanked by two SH3 domains. Here we report on the structural dynamic effects upon interaction of a phosphopeptide liga