✦ LIBER ✦
Investigation of selected toxicological parameters of γ-pentachlorocyclohexene (γ-PCCH)
✍ Scribed by Mazzag, E. ;Nagymajtenyi, L. ;Huszta, E. ;Desi, I. ;Macholz, R.
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 339 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0027-769X
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✦ Synopsis
The toxic effects of the y-hexachlorocyclohexane metabolite y-pentachlorocyclohexene (y-PCCH) were studied by acute and subacute (6 weeks) experiments. The investigations included cerebral convulsibility with chemoshock (Tetrazolium), reactivity with hot plate method, the learning ability with learning tests, and peripheral nervous activity (EMG). Nociceptive reaction time was not influenced, the learning process (6 weeks) was inhibited by y-PCCH. The conduction velocity of the peripheral nerve was decreased. At the end of the 6th week liver enlargement was found.